Thiem showed no mercy as he continued to dominate, racing into a 4-0 lead in a flash in the third set by mixing up his game expertly.
"I'm young. I might as well stay on court and entertain you guys", the 21-year-old Zverev joked with the crowd. "This definitely paid off, the hours in the gym every day ..." I'm happy with all of my game.
Murray has yet to make his return from hip surgery, though is expected to play at least part of the grass season, while the long-absent Djokovic has been working his way back to fitness and winning ways through the clay swing, and was into his 12th French Open quarter-final, his 40th Major quarter-final overall, with an eye on a ninth French semi.
The match started brightly, with the early signs living up to the thrilling contest that many were expecting, with Thiem securing the only break to go a set up.
"I didn't win it today, but it's a positive sign", said Khachanov.
Having beaten Zverev four times in six meetings in the past, the world number world eight has the firepower to progress further in the tournament but he needs to be at his best to stop the high-flying German.
Yes, Djokovic was thrilled to get back to a ninth consecutive quarterfinal in Paris after dealing with elbow trouble for more than a year and needing surgery in February.
Three-time champion Williams is playing her first Grand Slam tournament since taking time off last year due to pregnancy, while Sharapova is at Roland Garros for the first time in three years after serving a doping ban in 2016 and being refused a wildcard 12 months ago.
"I believe it is the matchup numerous followers in Germany and Austria had been hoping for after they noticed the draw", mentioned Thiem.
Zverev's smash at the net gave him match point, which he took when Khachanov netted a forehand.
Just seven matches into her comeback following a maternity break, Williams impressed all those watching on the 10,000-seater Suzanne Lenglen Court - including former boxing champion Mike Tyson - by pulverising her opponent. He then patted Khachanov, a friend from their junior days, on the chest before pumping his arms to celebrate. However, Zverev was now regularly clutching his hamstring after several rallies and had some heavy strapping applied after being broken for the second time in the set.
"Physically, obviously it's not easy to play, you know, back-to-back-to-back five-set matches, but I will manage it somehow". One of those points, when Nishikori could only flail at a ball down the line, brought up Thiem's first break point and Nishikori appeared about to smash his racket before stopping himself. Khachanov punished him and broke for 5-5.
In the women's event, Madisan Keys kicked off a good day for the Americans with a comfortable 6-1, 6-4 win over Romania's Mihaela Buzarnescu. "Hopefully big things can happen here".
She will now face compatriot Sloane Stephens for a place in the final. My first quarter. I lost to a great player.
Stephens - who performs both Caroline Wozniacki or Daria Kasatkina on Tuesday - snapped an 0-for-Four skid in French Open fourth rounds.
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