Williams' 6-3 6-3 finals loss to inspired German Angelique Kerber denied the American a record-equalling 24th grand slam singles crown.
Kerber looked understandably nervous as she served for the match at 5-3 but could celebrate when Williams netted a backhand on her first match point.
It also stopped her joining Court, Evonne Goolagong and Kim Clijsters as the only mothers to win Grand Slam titles in the professional era. The 36-year-old Williams is already a legend, but what she did at Wimbledon this year is nothing short of extraordinary.
After the match, during an interview, Serena got a bit emotional sharing that: 'It was such an unbelievable tournament for me. It's obviously disappointing but I can't be disappointed, I have so much to look forward to, you know, I'm literally just getting started.
Angelique Kerber has taken the first set 6-3 against Serena Williams in the Wimbledon final.
"From the first point to the last point, she played unbelievable today", Williams said of Kerber. Clijsters was younger then (26 and 27) than Williams is now, and she took a longer hiatus.
She had not faced anyone with the pedigree of the German though and was outmanoeuvred in the first set as Kerber's dogged defence forced too many errors.
'Today she played in the final at Wimbledon.
Williams had been favoured to draw level on Saturday but, despite turning 37 in September and suffering only her third defeat in 10 finals at The All England Club, the former world No.1 maintains more majors are still to come. You're such an inspiration for all of us and I'm sure you will have your next grand slam title soon.
Now she's dropped another.
'I'm really happy to get this far.
The world number 10, known for her returning prowess, will be hoping to engage Serena in long rallies in a bid to tire the veteran. They've played each other six previous times; Djokovic has won the last five, including two at Wimbledon, while Anderson's lone head-to-head victory came a decade ago.
Things went with serve at the beginning of the second set, but Kerber who was dominating the rallies, broke Williams again with a forehand down the line to go up 4-2. Markle and her sister-in-law Kate Middleton participated in a standing ovation as the players walked onto the court. "This is what I'm practicing for, this is the moment where I'm really looking forward to playing on the big stages against the best players and trying to play my best tennis".
Williams was asked what she'll tell her daughter, Olympia, about this tournament and this day.
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