Nadal, the defending champion in NY, was leading the first-round match 6-3 3-4 when Ferrer retired due to a suspected calf injury.
STATISTICAL BREAKDOWN Nadal  beat Ferrer 6-3 3-4 ret.
Moments later, Ferrer the 2013 French Open runner-up (to Nadal), announced to the crowd that this was his final Grand Slam event.
"I'm improving tournament after tournament, match after match".
Andy Murray was a victor in his return to Grand Slam tennis, beating James Duckworth 6-7 (5), 6-3, 7-5, 6-3 in the first round of the U.S. Open.
It marked the first time he'd ever retired from a Grand Slam match in his career.
The Brit leads head to head meetings 13-2, Verdasco only beat him at 2003 Segovia Challenger and 2009 Australian Open.
Second seed Roger Federer kicks off his quest for a sixth U.S. Open crown against Japan's Yoshihito Nishioka at the Arthur Ashe Stadium on Tuesday and Wimbledon champion Novak Djokovic is in action against Hungary's Marton Fucsovics.
Simona Halep crashed out in the first round, becoming the first No. 1 seed in the Open era to do so. That's life. Yeah, he deserved a better finish on a Grand Slam.
No. 1 Rafael Nadal vs. Vasek Pospisil: Nadal will hope to have an easier match when compared to Novak Djovokic at Arthur Ashe.
The 31-year-old was in real trouble when he went a break down early in the third set but he dug in to limit his losses and was urged on by his support camp, including wife Jelena.
It won't be an easy match for the American player, who reached semifinals here past year while Giorgi played the Wimbledon quarter-finals losing to Serena last month. "We've shared wonderful moments together. and he's one of the greatest players our country has ever had". "I was happy when I was drawn to play Rafa here, it was a gift play centre court with him".
Denis Shapovalov, the 19-year-old 28th seed, was 7-5, 5-7, 4-1 ahead of 18-year-old Felix Auger-Aliassime when his Canadian teammate and close friend was forced to retire.
The Spaniard who has three US Open titles, is in a good section of the draw.
Men's defending champion Nadal once again owns the top spot in the men's game, coming to Flushing riding a wave of momentum that's carried him through a stellar 2018 campaign.
The 44th-ranked Tiafoe had lost in the first round in NY in each of the past three years, including against Roger Federer in 2017.
He easily won the first two sets, then rallied to take the third after receiving treatment on his legs early in the set.
At 3hr and 17min on the new Louis Armstrong Stadium, it was Murray's longest match since his comeback in a reassuring indication of his fitness.
After winning the US Open in 2016 Wawrinka was unable to defend his title previous year after two surgeries on his left knee.
Several players requested medical attention due to the heat during their matches on Monday while some on the women's side opted to take advantage of a 10-minute heat break between the second and third sets of their matches.
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