"This is a time when your father, when your husband, when your brother, when your son could do great", Trump said, who then changed the inflection of his voice to dread as he intoned a conversation between the accused and his mother.
The nomination has become a politically explosive issue ahead of November 6 elections, when control of Congress is at stake.
Senators are waiting for the FBI's reopened background check on the accusations against Mr Kavanaugh, who has denied the claims by all three women.
"Thirty-six years ago, this happened".
The ad also points to McCaskill's work with President Trump on legislation aimed at combating the nation's opioid epidemic and helping veterans.
Some Republicans and White House allies have suggested the allegations against Kavanaugh can be potent political fodder in the run-up to November 6, animating GOP voters who have so far lacked the same motivation to head to the polls as their Democratic counterparts.
Trump has said he found Ford's testimony "very compelling". 'I don't remember.' How did you get there? "There's been a lot of people over the a year ago that have lied to Congress", Trump said. I respect her position very much.
"Any lawyer will tell you that she said-he said situations are some of the hardest and most painful cases to review, and that remains true here", Scott said in the statement.
Mr Trump's comments came as Senate Majority Leader Mitch McConnell accused Democrats of opening "the flood gates of mud and muck" against Mr Kavanaugh.
Sens. Joe Manchin (D-WV), Heidi Heitkamp (D-ND), and Joe Donnelly (D-IN) are other red-state Democrats whose election bids might be impacted by the hearings and their votes on Kavanaugh.
Senator Dianne Feinstein, the Judiciary Committee's top Democrat, said a Friday vote on Kavanaugh would not give senators enough time to evaluate the Federal Bureau of Investigation probe.
An FBI investigation is an important step, and should be completed.
What the evidence shows us is that none of the witnesses provided by Dr. Ford can corroborate her story, or even basic events of the night in question. The fourth, Deborah Ramirez, accuses Kavanaugh of thrusting his exposed penis in her face at a college party.
The FBI is investigating Blasey's allegation that a drunken, teenaged Kavanaugh pinned her on a bed, groped her and covered her mouth when she tried to scream during a gathering of high school friends.
He had previously called her a "very credible witness".
He launched into a hypothetical riff about a young man who got a job at IBM or General Motors but is falsely accused of sexual assault.
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