His second was a fine curling effort with his right foot from Ousmane Dembele's pass.
Sevilla took the lead twice in the first half from a Jesus Navas counter-attack strike and Gabriel Mercado's eight-yard finish.
Messi finally put Barcelona in charge when he nonchalantly chipped the ball over on-rushing goalkeeper Tomas Vaclik. "His stats this season are 12 goals from 30 appearances, he is performing, yet he is still the whipping boy", Berbatov told Betfair.
If Madrid wins both matches, they will not only advance to the Spanish Cup Final but nearly eliminate the gap to their biggest rivals in the league standings, which means the La Liga championship will be up for grabs with three teams - Barça, Madrid, and Atlético Madrid - having equal chances to take the trophy. He has also struck six trebles for Argentina.
Sevilla fell into fifth place, with Getafe moving up into the Champions League spots after beating Rayo Vallecano 2-1.
But they were soon pegged back by an unstoppable volley from Messi.
"We have a decisive and superlative player".
"You go through different spells in a season".
"After that, we will think about the La Liga game there - but we want to win everything".
Messi leads the statistics for Europe's five major leagues, with 25 goals and 11 assists so far this season.
"We went through a patch when we weren't playing our best and that makes everything more hard".
Yet that contest will come just three days on from Madrid's visit to Levante, while Barca have a four-day gap following their 4-2 victory at Sevilla on Saturday.
"We won't give up in any competition". They will be really up for it, but we will do everything possible to reach the cup final.
However, Casemiro went to ground after Cheick Doukoure appeared to make the slightest contact with his shin with a rash attempted clearance, and Bale confidently dispatched the penalty once referee Ignacio Iglesias Villanueva was happy to let the call stand.
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