The south-coast side had a great early opportunity as Nathan Redmond broke the offside trap and ran through on goal, only for Gunners goalkeeper Bernd Leno to rush off his line and block the shot.
'It is because Iwobi can open space on the overlap for them. Matt Targett also replaced Ryan Bertrand, who similarly was relegated to the bench.
The ball took a deflection off Bednarek but Mkhitaryan thumped the ball low and hard beyond Gunn.
'The connection was good between the players, ' said the midfielder.
The kick-off time for the match is 8:45 pm.
Late on, substitute Pierre-Emerick Aubameyang could have added a third but his cross-shot towards Lacazette was kept out by Gunn's trailing leg. In this game past year, Arsenal stormed back from 2-0 down to win while, in this season's reverse fixture, they traded blows before Charlie Austin decided matters.
While they have now won their last seven league matches in a row at The Emirates, their away performances have been patchy.
His goal against Southampton, however, was his fourth league goal of the season and it should provide him with a much needed confidence boost - particularly if he continues chalking up assists like he did for Alexandre Lacazette's opening goal.
Speaking after the match, Emery admitted that his side were starting to play to his style and even singled out Arsenal's fringe players for adapting quickly during the club's busy fixture schedule.
"We are not looking at the table at the moment because we still have lots of games to play", he said. It was his cross which Mkhitaryan turned goalwards for Lacazette's opener, and another which was finished off by Mkhitaryan to double the lead. Here are the player ratings from the 5-1 win.
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