Nursing union SATSE said Madrid's hospitals were on "the verge of collapse" and needed urgent support, while a doctors' union said it had filed a lawsuit demanding protective equipment within 24 hours.
China's death toll officially stands at 3,285, while the figure in Italy, the country with the most deaths, is 6,820.
Out of the total 18 COVID-19 infected persons in the state, one person was discharged from the hospital and one death, the total number of patients now are 16.
As of Wednesday morning, New York City had recorded 192 deaths - almost 100 more than any other county or state in the country.
More than 428,000 people worldwide have been infected by the virus and more than 19,000 have died, according to Johns Hopkins University.
Fernando Simón, head of Spain's health emergency coordination center, said he hoped the numbers would peak soon.
"It is an increase similar to what we saw yesterday and in the past few days and different, less, than what we saw last week". The death toll in Italy surpassed that of China last week as the infection overwhelmed its health system.
Even before the clampdown, life in the state started slowing down with roads having limited traffic, largely absent public transport and many shops downing their shutters.
Donald Trump vows to reopen U.S. economy, despite coronavirus.
The Dow Jones Industrial Average on Tuesday surged 11.3 percent, its biggest rally since 1933 during the Great Depression. China's Hubei province, where the outbreak was first spotted late past year, started lifting its lockdown.
The provincial capital Wuhan - the ground zero of the outbreak after it was initially detected at a market that sold wild animals for human consumption - will allow residents to leave from April 8.
The deal also includes face masks, gloves and respirators.
India's stay-at-home order is now the biggest, and Russian Federation will follow suit, with President Vladimir Putin declaring next week a public holiday and postponing a public vote on constitutional reforms.
In New Zealand, the government declared an emergency before an unprecedented lockdown begins late Wednesday.
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